Author Archives: DrE

Friday Funnies!

~E

Why we get sick when the weather is cold

Have you, as I have, noticed that many of your friends and acquaintances are sick this winter? Or maybe you yourself got the cold or flu?

We are told that it’s an old wife’s tale that cold weather makes us sick.

Well, it turns out that the old wife’s tale is true!

 

A new study, “Cold exposure impairs extracellular vesicle swarm–mediated nasal antiviral immunity,” coauthored by six scientists, published in The Journal of Allergy and Clinical Immunology, Dec. 6, 2022, found the underlying biological mechanisms for why there is seasonal variation in respiratory viral infections.

Below are excerpts from the article:

Upper respiratory tract infections (URIs) pose a significant public health burden in terms of decreased productivity, absenteeism at work or school, and health care system overload. URIs may be associated with multiple clinical sequelae, such as otitis media, sinusitis, bronchiolitis, pneumonia, and exacerbation of asthma or chronic obstructive pulmonary disease.

Seasonal variation in increased URI prevalence, morbidity, and mortality during the winter period has been well recognized. These adverse outcomes may be further exacerbated by socioeconomic and behavioral factors as well as age, sex, and comorbidities…. Accumulating evidence suggests that temperature and humidity may independently or jointly contribute to the risk of respiratory viral infections due to changes in host susceptibility. Similarly, recent fundamental research exploring the underlying molecular mechanisms demonstrates that cold temperature may impair host innate immune response to viral infections.

The nasal cavity is one of the initial contact points between the external environment and the human body; it is highly sensitive to changes in ambient temperature. The nasal mucosal barrier therefore represents the front line of defense against exposure to inhaled respiratory pathogens through multiple host immune mechanisms. The physical barrier function of the nasal mucosa can prevent pathogens from entering the body through the production of mucus glycoproteins, mucociliary clearance, and epithelial tight junctions. The nasal epithelial cells also play important roles in the initiation, maintenance, and regulation of innate immunity. These defense mechanisms are constitutive and can be activated by both membrane-bound and cytoplasmic pattern recognition receptors that recognize pathogen-associated molecular patterns commonly found in viruses. One of the best characterized classes of pattern recognition receptors is the Toll-like receptor (TLR)family, which are transmembrane receptors expressed on multiple cell types, including nasal epithelial cells. TLRs recognize components of invading microbes and trigger the first line of innate immune and inflammatory responses to combat infectious agents. Within the TLR family, TLR3 is considered a major mediator of cellular defense to viral infection, as it responds to double-stranded RNA (dsRNA), a common by-product of virus replication. While these strategies occur at the level of the epithelial cell, recent evidence has shown that active host mucosal defense to bacteria extends into the mucus itself through the epithelial release of antimicrobial extracellular vesicle (EV) swarms. EVs are lipid-bound vesicles secreted by cells into the extracellular space and have been reported in virtually all human biological fluids, including blood, lymph, and nasal mucus…. Accumulating evidence has shown that in addition to their previously described antibacterial role, EVs may also regulate innate immune responses to viral infections. This occurs through the functional delivery of antiviral agents, such as microRNAs (miRNAs), into neighboring or distant recipient cells…. Previous studies have reported that several miRNAs have direct antiviral effects or regulate the inflammatory pathways, thereby enhancing antiviral immunity against infections. In addition to transport of antiviral agents between cells, EVs can also exert direct virion neutralization by binding to virus ligands via surface receptors and block their entry to host cells.

The scientists ran a number of experiments and found that when the temperature is reduced by as little as 5 degrees Centigrade, “Cold exposure impairs TLR3-dependent EV secretion and miR-17 abundance, which abrogates antiviral activity.” In other words, exposure to cold temperature impairs the body’s secretion of the extracellular vesicles (EV) that regulate our bodies’ innate immune responses to viral infections. 

The study concludes:

[T]he potent antiviral functions mediated by TLR3-dependent EVs are impaired by cold air conditions via a 41.9% decrease in total EV release as well as reduced miRNA packaging (23.8%) and antiviral surface receptor binding activity (24.4% and 77.2%) of individual EV….

Many respiratory viruses initiate infection in the nasal cavity, which is the first region of contact of inhaled respiratory pathogens and is highly sensitive to changes in ambient air temperature. The diminished innate immune responses to viral infections at cool temperatures could thereby create a more permissive environment for virus replication compared to warm temperatures…. [I]nhaling cool air in the winter season might impair the antiviral immune defense functions mediated by TLR3-stimulated EVs and decrease resistance to infections by reducing the host cell temperature within the anterior nasal mucosa. Our observations revealed that exposure to cold resulted in increased host susceptibility to respiratory viruses, providing a potential immunologic mechanism for seasonal variation in URIs.

~E

Wednesday funnies!

 

~E

The virtue-signaling mayor caption contest

This is our world-famous 265th Caption Contest!

Here’s the pic:

About the pic: New York Post reports that after “dying to go” to the Metropolitan Gala “for years,” New York City Mayor Eric Adams, a Democrat, finally got his wish. Adams, 61, arrived at the May 2022 Met Gala wearing a statement suit adorned with custom art from Laolu, a Nigerian artist who is based in New York City.

You know the drill:

  • Enter the contest by submitting your caption as a comment on this thread (scroll down until you see the “LEAVE A REPLY” box).
  • Body and Soul‘s writers will vote for the winner.
  • Any captions proffered by our writers, no matter how brilliant (ha ha), will not be considered. :(

This contest will be closed at the end of Tuesday, January 17, 2023.

‘To get the contest going, here’s my caption:

Meanwhile, new12brooklyn reports that “Gun violence is on the rise in New York City.” So much for virtue signaling….

For the winner of our last Caption Contest, go here.

~E

We have a winner!

WE HAVE A WINNER FOR OUR 264th CAPTION CONTEST!

Our writers dutifully voted for their #1 and #2 captions. Each #1 vote is worth 4 points; each #2 vote us worth 2 points.

And the clear winner, with three #1 votes, totaling 12 points, is:

Jackie Puppet!

Here’s his caption:

Does this mustache go with my dress?

Auntie Lulu and Brian Heinz (each with one #1 vote), and greenworxx and vett (each with two #2 votes) are in second place, each with 4 points:

Auntie Lulu: “I wonder if this tool will be wearing his red dress to prison?”

Brian Heinz: “Well it looks like we lost Mr. Clean to the trans sect.”

greenworxx: “Tranny, liar, nutter, thief…..too bad he’ll soon be full of grief!”

vett: “Now there’s a face not even a mother could love.”

Calgirl is in third place, with one #2 vote and 2 points:

“Check me out: I don’t even require “underwire” or exposed bra straps with this dress. Who knew?”

WELL DONE, EVERYONE!

Congratulations, Jackie Puppet!

For all the other caption submissions, go here.

Be here later today for our next Caption Contest!

~E

Saturday Funnies!

~E

The Tranny-Luggage-Thief Caption Contest

This is our world-famous 264th Caption Contest!

Here’s the pic:

About the pic: The bald transvestite in the pic above is Sam Britton, a self-described “non-binary,” who has served since June 19, 2022 as the Biden administration’s deputy assistant secretary of energy. He celebrated his appointment with a Twitter post photo of himself in a chic red dress and high heels. He has a well-documented career leading workshops on “pup play,” a sexual practice in which the partner plays the role of a pet dog within a domination/submission dynamic.

In September, Britton allegedly stole a high-end piece of checked luggage worth over $2,000 from a baggage carousel at the Minneapolis-Saint Paul airport. Video surveillance shows him at the baggage claim despite having checked no luggage of his own. He then appears to take the bag and remove its rightful owner’s nametag. Over the next month, Brinton used the bag as his own on multiple other trips. When eventually questioned by police, he confirmed that the bag was in his possession and claimed he’d made a mistake due to exhaustion. On October 27, Brinton was charged with felony theft of movable property without consent, which is punishable by up to five years in prison and a $10,000 fine. He faces a court hearing on December 19. (Source: Spectator)

You know the drill:

  • Enter the contest by submitting your caption as a comment on this thread (scroll down until you see the “LEAVE A REPLY” box).
  • Body and Soul‘s writers will vote for the winner.
  • Any captions proffered by our writers, no matter how brilliant (ha ha), will not be considered. :(

This contest will be closed at the end of Tuesday, December 20, 2022.

‘To get the contest going, here’s my caption:

Just another freak to add to an already criminal administration.

For the winner of our last Caption Contest, go here.

~E

We have a winner!

Note: Please forgive me for being so late in posting the results of our last Caption Contest. My life had gone through great changes in the last year, making the big exodus out of a blue state to a red state where I am very happy. But my daily routine changed, and I need to return to a routine of regular posting on this blog, which I will. Once again, please forgive!

***************************************************************************

We have a winner FOR OUR 263rd CAPTION CONTEST!

Our writers dutifully voted for their #1 and #2 captions. Each #1 vote is worth 4 points; each #2 vote us worth 2 points.

And the clear winner, with three #1 votes, totaling 12 points, is:

Brian Heinz!

Here’s his caption for the video below:

Little Lord Fauci Roy,
tried to throw the ball,
but got booed by us all,
we honor him now for all to see,
how much money he’s made off thee.
He said the jab was good and yes you should.
His lies got better but people got deader,
so now we say, don’t go the Fauci way
you might not be here another day.

Auntie Lulu and Captain America are in second place, each with one #1 vote and one #2 vote, totaling 6 points:

Auntie Lulu: “What kind of nitwit would propose that Anthony Fauci receive any kind of “honorary” award?”

Captain America: “Me and Bill Gates are gonna kill all you bullies who used to call us names, and never let us play in any reindeer games.”

greenworz, GregB, and vett are in third place, each with one #2 vote and 2 points:

greenworz: “I’ll clap and cheer when Fauci is hanging by the neck for his contributions in using “gain of function” technology to make the covid virus more harmful and aiding the pharmaceutical companies in formulating the maiming, deadly and depopulating injection formulas.”

GregB: “The modern day ‘Angel of Death’ and protege of Dr. Joseph Mengele, Dr. Fear Fuhrer ‘Foul-Chi’ is greeted in Seattle by both ‘woke’ and ‘awake’ baseball fans.”

vett: “I suggest giving him a blindfold, a cigarette, and a 21 gun salute.”

WELL DONE, EVERYONE!

Congratulations, Brian Heinz!

For all the other caption submissions, go here.

Be here later today for our next Caption Contest!

~E

The “Lord Fauci” Caption Contest

This contest is now closed.
—————————–

This is our world-famous 263rd Caption Contest!

Here’s the video:

About the video: On August 10, 2022, 81-year-old Dr. Anthony Fauci, Director of the NIH’s National Institute of Allergy and Infectious Diseases, was in Seattle for a Mariners’ game where he was set to receive an honorary award and throw out the first pitch at a Major League ball game against the visiting Yankees. He was met with applause and scattered boos.

You know the drill:

  • Enter the contest by submitting your caption as a comment on this thread (scroll down until you see the “LEAVE A REPLY” box).
  • Body and Soul‘s writers will vote for the winner.
  • Any captions proffered by our writers, no matter how brilliant (ha ha), will not be considered. :(

This contest will be closed at the end of Tuesday, November 1, 2022.

‘To get the contest going, here’s my caption:

Like trained seals, Seattle blue-zombies honor the man who gave millions of dollars to help fund the Wuhan Lab that unleashed the COVID-19 virus upon the world.

For the winner of our last Caption Contest, go here.

~E

We have a winner!

 

…FOR OUR 262nd CAPTION CONTEST!

Our writers dutifully voted for their #1 and #2 captions. Each #1 vote is worth 4 points; each #2 vote us worth 2 points.

And the winner, with two #1 votes, totaling 8 points, is:

vett!

Here is the winning caption:

But…but mommy promised me I’d be king.

Brian Heinz (with one #1 vote and one #2 vote) and Auntie Lulu (with three #2 votes) are in 2nd place, each with 6 points:

Brian Heinz: “Hey Lisa, did you hear the one about the prince that got dethroned, Harry somebody?”

Auntie Lulu: “Gosh! What did I do? I’m just tryin’ to support my little woman and the kids.”

Captain America and greenworxx are in 3rd place, each with one #1 vote and 4 points:

Captain America: “If I were King of the Forrrrest!!!”

greenworxx: “Being treated as if he’s invisible irritates poor spoiled Harry.”

Truckjunkie is in 4th place, with one #2 vote and 2 points:

Truckjunkie: “How DARE that jackass William claim his rightful place as King…..”

WELL DONE, EVERYONE!

Congratulations, vett!

For all the other captions, go here.

Be here tomorrow for our next Caption Contest!

~E